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Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice
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He led the research team that identified 5-Amino 1MQ as a selective NNMT inhibitor, conducted the proof-of-concept obesity reversal studies in diet-induced obese mice, and founded Ridgeline Therapeutics to advance the compound toward FDA approval
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