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An 8-week trial in obese males at 25 mg per day measured specific bone marker changes: Carboxy-terminal propeptide of type I procollagen (a bone formation marker) increased 23% at two weeks (P less than 0.01) Osteocalcin (another bone formation marker) increased 15% at eight weeks (P less than 0.01) NTX (N-terminal cross-linking telopeptide, a bone resorption marker that signals how fast old bone is being broken down) increased 27-46% [15] Key Research Highlights: Bone formation and resorption markers both elevated (turnover acceleration, not selective formation) Osteocalcin +15% at 8 weeks in obese males Long-term bone mineral density effects not established MK-677 Research in Growth Hormone Deficiency A dose-escalation study in adults with GH deficiency evaluated MK-677 at 10-50 mg per day across sequential dosing periods

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