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Published in-vitro and animal-model studies have characterised IRR activation in relation to: • Inflammatory signalling cascades • Cytokine expression profiles • Apoptotic and oxidative-stress markers • Tissue-remodelling and regeneration models • Neuronal-signalling models Published work also reports that cibinetide does not substantially activate the homodimeric erythropoietin receptor associated with erythropoiesis, which is why it is frequently used as a comparator to EPO in receptor-selectivity experiments
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Quality control (QC) samples were prepared by spiking fresh rat plasma with an appropriate dilution of dihexa for the final concentration of dihexa specified, keeping a 10: 1 ratio of plasma to dihexa solution (final DMSO concentration 5%)
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